Attempted Synthesis of Vinca Alkaloids Condensed with Three-Membered Rings
نویسندگان
چکیده
منابع مشابه
Vinca Alkaloids
Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant. They are naturally extracted from the pink periwinkle plant, Catharanthus roseus G. Don and have a hypoglycemic as well as cytotoxic effects. They have been used to treat diabetes, high blood pressure and have been used as disinfectants. The vinca alkaloids are also important for being cancer fighters. There ar...
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Addition of low order phenyldimethylsilylcyanocuprates to allenes followed by "in situ" reaction of the intermediate silylcuprate with electrophiles ("the silylcuprate strategy") provides new routes for the synthesis of functionalised allylsilanes, which undergo highly stereocontrolled silicon-assisted intramolecular cyclizations leading to three to seven membered ring-formation.
متن کاملEffect of vinca alkaloids on intestinal absorption of glucose.
Vinca alkaloids are well known for their antimitotic and antitumor activities. It inhibits transcription and translation 0, 2, 3). Vinca alkaloids cause specific mitotic arrest of cells. The drugs derived from these alkaloids are: Vinblastine and vincrystine. These drugs have been extensively used for studying the nature of cell arrest and the associated changes in various clinical (neoplastic ...
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Organocatalysis, now running its second decade of life, is being considered one of the main tools a synthetic chemist has to perform asymmetric catalysis. In this review the synthesis of six-membered rings, that contain multiple chiral centers, either by a ring closing process or by a functionalization reaction on an already existing six-membered ring, utilizing bifunctional (thio)ureas will be...
متن کاملThe Vinca Alkaloids: a New Class of Oncolytic Agents.
A phytochemical investigation of the plant Vinca ro@eaLinn. has demonstrated that a number of alkaloidal substances can be obtained with antitumon activity. Over 30 alkaloids have been obtained, of which four—vinbiastine, vinleunosine, vincnistine, and vinrosidine—are known definitely to be active. Chemically these compounds are closely related to one another and to two monomeric alkaloids,...
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ژورنال
عنوان ژورنال: Molecules
سال: 2018
ISSN: 1420-3049
DOI: 10.3390/molecules23102574